Kourosh Honarmand Ebrahimi

Work

King's College London

United Kingdom of Great Britain and Northern Ireland

King's College London

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Lecturer in Immunology and Drug Discovery

United Kingdom of Great Britain and Northern Ireland

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University of Oxford

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PDRA Advanced Metabolomics

United Kingdom of Great Britain and Northern Ireland

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University of Oxford

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Postdoc & Mass spectrometry research officer

United Kingdom of Great Britain and Northern Ireland

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University of Oxford

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Postdoc

United Kingdom of Great Britain and Northern Ireland

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University of Oxford

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EMBO Fellow & visiting postdoc

United Kingdom of Great Britain and Northern Ireland

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Delft University of Technology

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Postdoctoral Research Associate

Netherlands

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Scripps Florida

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Postdoctoral Research Associate

US

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Technische Universiteit Delft Faculteit Technische Natuurwetenschappen

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PhD / Bioinorganic Chemistry

Netherlands

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Education

Technische Universiteit Delft Faculteit Technische Natuurwetenschappen

Netherlands
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M.Sc / Biochemical Engineering

Islamic Azad University, Tehran

Iran (Islamic Republic of)
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B.Eng, Chemical Engineering, Petroleum Process Design

Publications

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters

journal-article

The [2Fe-2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2-regulated nitric oxide access tunnel

FEBS Letters

journal-article

Controlling nanocage assembly, towards developing a one-health “plug & play” platform for targeted therapy

Chemical Communications

journal-article

A Versatile Virus-Mimetic Engineering Approach for Concurrent Protein Nanocage Surface-Functionalization and Cargo Encapsulation

Small

journal-article

A Versatile Virus‐Mimetic Engineering Approach for Concurrent Protein Nanocage Surface‐Functionalization and Cargo Encapsulation

Small

journal-article

Ancient complexes of iron and sulfur modulate oncogenes and oncometabolism

Current Opinion in Chemical Biology

journal-article

VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products

Chemical Communications

journal-article

Density dependent regulation of inflammatory responses in macrophages

Frontiers in Immunology

journal-article

Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations

Frontiers in Molecular Biosciences

other

Iron–sulfur clusters as inhibitors and catalysts of viral replication

Nature Chemistry

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Iron–sulfur clusters as inhibitors and catalysts of viral replication

Nature Chemistry

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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis

EBioMedicine

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Hidden in Plain Sight: Natural Products of Commensal Microbiota as an Environmental Selection Pressure for the Rise of New Variants of SARS‐CoV‐2

Chembiochem : a European journal of chemical biology

journal-article

A lipidomic view of SARS-CoV-2

Bioscience Reports

journal-article

A lipidomic view of SARS-CoV-2

Bioscience Reports

other

Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium

Stem Cell Reports

journal-article

Interferon‐stimulated gene products as regulators of central carbon metabolism

The FEBS Journal

journal-article

Interferon-stimulated gene products as regulators of central carbon metabolism

The FEBS journal

journal-article

Ferritin as a Platform for Creating Antiviral Mosaic Nanocages

Chembiochem : a European journal of chemical biology

other

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

Nature Communications

journal-article

Nanofactories for Controlled Synthesis and Delivery of Nucleoside Analogue Therapeutics

Chembiochem : a European journal of chemical biology

other

A Chemical-Physical View of the Interpretation of Wavefunction

other

Cover Feature: Mechanism of Diol Dehydration by a Promiscuous Radical‐SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2) (ChemBioChem 11/2020)

ChemBioChem

journal-article

Mechanism of Diol Dehydration by a Promiscuous Radical‐SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2)

ChemBioChem

journal-article

Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2)

Chembiochem : a European journal of chemical biology

journal-article

SARS‐CoV‐2 spike glycoprotein‐binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection

FEBS Letters

journal-article

SARS-CoV-2 spike glycoprotein-binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection

FEBS Letters

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Viperin, through its radical‐SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication

FEBS Letters

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Viperin, through its radical‐SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication

FEBS Letters

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ddhCTP produced by the radical‐SAM activity of RSAD2 (viperin) inhibits the NAD+‐dependent activity of enzymes to modulate metabolism

FEBS Letters

journal-article

ddhCTP produced by the radical-SAM activity of RSAD2 (viperin) inhibits the NAD+ -dependent activity of enzymes to modulate metabolism

FEBS Letters

journal-article

Fast and accurate enzyme activity measurements using a chip-based microfluidic calorimeter

Analytical Biochemistry

journal-article

Fast and accurate enzyme activity measurements using a chip-based microfluidic calorimeter

Analytical Biochemistry

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A unifying view of the broad-spectrum antiviral activity of RSAD2 (viperin) based on its radical-SAM chemistry

Metallomics

journal-article

A unifying view of the broad-spectrum antiviral activity of RSAD2 (viperin) based on its radical-SAM chemistry

Metallomics

journal-article

Evidence for the synthesis of an unusual high spin (S = 7/2) [Cu–3Fe–4S] cluster in the radical-SAM enzyme RSAD2 (viperin)

Chemical Communications

journal-article

Evidence for the synthesis of an unusual high spin (S= 7/2)[Cu–3Fe–4S] cluster in the radical-SAM enzyme RSAD2 (viperin)

Chemical Communications

journal-article

The radical‐SAM enzyme Viperin catalyzes reductive addition of a 5′‐deoxyadenosyl radical to UDP‐glucose in vitro

FEBS Letters

journal-article

The radical‐SAM enzyme Viperin catalyzes reductive addition of a 5′‐deoxyadenosyl radical to UDP‐glucose in vitro

FEBS Letters

journal-article

Spectroscopic evidence for the presence of a high‐valent Fe(IV) species in the ferroxidase reaction of an archaeal ferritin

FEBS Letters

journal-article

The workings of ferritin: a crossroad of opinions

Metallomics

journal-article

Spectroscopic evidence for the role of a site of the di-iron catalytic center of ferritins in tuning the kinetics of Fe(ii) oxidation

Molecular BioSystems

journal-article

Accurate label-free reaction kinetics determination using initial rate heat measurements

Scientific Reports

journal-article

Self-assembly is prerequisite for catalysis of Fe(II) oxidation by catalytically active subunits of ferritin

J. Biol. Chem.

journal-article

Unity in the Biochemistry of the Iron-Storage Proteins Ferritin and Bacterioferritin

Chem. Rev.

journal-article

Unity in the Biochemistry of the Iron-Storage Proteins Ferritin and Bacterioferritin

Chemical Reviews

journal-article

Mass Spectrometry Approach and ELISA Reveal the Effect of Codon Optimization on N-Linked Glycosylation of HIV-1 gp120

J. Proteome Res.

journal-article

The Amyloid Precursor Protein (APP) Does Not Have a Ferroxidase Site in Its E2 Domain

PLoS ONE

journal-article

A Conserved Tyrosine in Ferritin Is a Molecular Capacitor

ChemBioChem

journal-article

The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement

Nat Chem Biol

journal-article

Phosphate accelerates displacement of Fe(III) by Fe(II) in the ferroxidase center of Pyrococcus furiosus ferritin

FEBS Letters

journal-article

The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement

Nat Chem Biol

journal-article

A Synthetic Peptide with the Putative Iron Binding Motif of Amyloid Precursor Protein (APP) Does Not Catalytically Oxidize Iron

PLoS ONE

journal-article

A novel mechanism of iron-core formation by Pyrococcus furiosus archaeoferritin, a member of an uncharacterized branch of the ferritin-like superfamily

J Biol Inorg Chem

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The catalytic center of ferritin regulates iron storage via Fe (II)-Fe (III) displacement

Nature Chemical Biology

journal-article

Inhibition and stimulation of formation of the ferroxidase center and the iron core in Pyrococcus furiosus ferritin

J Biol Inorg Chem

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Catalysis of iron core formation in Pyrococcus furiosus ferritin

J Biol Inorg Chem

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